Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Requirements for selective recruitment of Ets proteins and activation of mb-1/Ig-alpha gene transcription by Pax-5 (BSAP).

Nucleic acids research - 1 Oct 2003

Maier Holly, Ostraat Rachel, Parenti Sarah, Fitzsimmons Daniel, Abraham Lawrence J, Garvie Colin W, Hagman James

Abstract excerpt

Pax-5, a member of the paired domain family of transcription factors, is a key regulator of B lymphocyte-specific transcription and differentiation. A major target of Pax-5-mediated activation is the mb-1 gene, which encodes the essential transmembrane signaling protein Ig-alpha. Pax-5 recruits three members of the Ets family of transcription factors: Ets-1, Fli-1 and GABPalpha (with GABPbeta1), to assemble...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD79 Antigens
Share to Macromolecular Substances

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to PAX5 Transcription Factor

Share to Proto-Oncogene Protein c-ets-1

Share to Proto-Oncogene Protein c-fli-1

Share to Proto-Oncogene Proteins c-ets

Share to Receptors, Antigen, B-Cell

Share to Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 14500810
DOI: 10.1093/nar/gkg785
PMCID: PMC206479

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Requirements for selective recruitment of Ets proteins and activation of mb-1/Ig-alpha gene transcription by Pax-5 (BSAP).PMID 14500810Read ↗

The Highly Conserved β-Hairpin of the Paired DNA-Binding Domain Is Required for Assembly of Pax-Ets Ternary ComplexesSemantic proximity Read ↗

The regulation of the B‐cell gene expression programme by Pax5Semantic proximity Read ↗

Loss- and gain-of-function mutations reveal an important role of BSAP (Pax-5) at the start and end of B cell differentiation.Semantic proximity Read ↗

C-terminal activating and inhibitory domains determine the transactivation potential of BSAP (Pax-5), Pax-2 and Pax-8.Semantic proximity Read ↗

PAX5 is part of a functional transcription factor network targeted in lymphoid leukemiaSemantic proximity Read ↗

Early B-cell factor, E2A, and Pax-5 cooperate to activate the early B cell-specific mb-1 promoter.Semantic proximity Read ↗

Rack1 regulates B-cell development and function by binding to and stabilizing the transcription factor Pax5Semantic proximity Read ↗

Pax5/BSAP maintains the identity of B cells in late B lymphopoiesis.Semantic proximity Read ↗

PAX5/TEL Acts as a Transcriptional Repressor Causing Down-modulation of CD19, Enhances Migration to CXCL12, and Confers Survival Advantage in pre-BI CellsSemantic proximity Read ↗

EBF1 and PAX5 control pro-B cell expansion via opposing regulation of the Myc geneSemantic proximity Read ↗

The B-Cell-Specific Transcription Factor and Master Regulator Pax5 Promotes Epstein-Barr Virus Latency by Negatively Regulating the Viral Immediate Early Protein BZLF1Semantic proximity Read ↗

Functional Heterogeneity of PAX5 Chimeras Reveals Insight for Leukemia DevelopmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.