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Article

Independent regulation of the two Pax5 alleles during B-cell development.

Nature genetics - 1 Apr 1999

Nutt S L, Vambrie S, Steinlein P, Kozmik Z, Rolink A, Weith A, Busslinger M

Abstract excerpt

The developmental control genes of the Pax family are frequently associated with mouse mutants and human disease syndromes. The function of these transcription factors is sensitive to gene dosage, as mutation of one allele or a modest increase in gene number results in phenotypic abnormalities. Pax5 has an important role in B-cell and midbrain development. By following the expression of individual Pax5 alleles at...

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PMID: 10192389
DOI: 10.1038/7720

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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