Article
Polymorphisms in WNT6 and WNT10A and colorectal adenoma risk.
Nutrition and cancer - 1 Jan 2011
Galbraith Rachel L, Poole Elizabeth M, Duggan David, Muehling Jill, Hsu Li, Makar Karen, Xiao Liren, Potter John D, Ulrich Cornelia M
Abstract excerpt
The WNT/β-catenin signaling pathway upregulates transcription of genes involved in cell proliferation and cancer progression; it has been implicated in colorectal adenoma formation. To date, no studies have examined polymorphisms in WNT genes or WNT gene-environment interactions in relation to adenoma risk. Within a colonoscopy-based case-control study of 628 adenoma cases and 516 polyp-free controls, we analyzed...
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