Article
Colorectal adenoma risk is modified by the interplay between polymorphisms in arachidonic acid pathway genes and fish consumption.
Carcinogenesis - 1 Feb 2005
Siezen Christine L E, van Leeuwen Astrid I M, Kram Nicolien R, Luken Manon E M, van Kranen Henk J, Kampman Ellen
Abstract excerpt
Associations between polymorphisms in genes (SNPs) involved in the arachidonic acid (AA) pathway and colorectal adenomas have been investigated in a Dutch case control study including 384 cases and 403 polyp-free controls. Twenty-one polymorphisms in seven candidate genes were studied and a potential modifying effect of fish consumption was considered. A protective effect on colorectal adenomas was found for the...
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