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Article

Genetic variability in prostaglandin synthesis, fish intake and risk of colorectal polyps.

Carcinogenesis - 1 Jun 2007

Poole Elizabeth M, Bigler Jeannette, Whitton John, Sibert Justin G, Kulmacz Richard J, Potter John D, Ulrich Cornelia M

Abstract excerpt

Dietary polyunsaturated fatty acids (PUFAs) can be converted to prostaglandins and leukotrienes. Metabolism of omega-6 (n-6) PUFAs results in the production of pro-inflammatory mediators whereas downstream products of omega-3 (n-3) PUFAs have lower inflammatory activity. Elevated n-3 PUFA intake from dietary fish may be associated with lower risk of colorectal neoplasia among those with genetic variants resulting...

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Source

Identifiers

PMID: 17277229
DOI: 10.1093/carcin/bgm026

Genes

ALOX5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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