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Article

Alpha-difluoromethylornithine resistance in Leishmania donovani is associated with increased ornithine decarboxylase activity.

Molecular and biochemical parasitology - 1 Feb 1990

Coons T, Hanson S, Bitonti A J, McCann P P, Ullman B

Abstract excerpt

The promastigote form of Leishmania donovani is sensitive to growth inhibition by DL-alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase (ODC), the first enzyme of the polyamine biosynthetic pathway, with an EC50 value of approximately 30 microM. Exposure of a wild type (DI700) cell population to gradually increasing concentrations of DFMO resulted in the selection of a strain of...

Topics

Affinity Labels
Amino Acids
Animals
Arginase
Biogenic Polyamines
DNA
DNA Restriction Enzymes
Drug Resistance
Eflornithine
Leishmania donovani
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ornithine Decarboxylase

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PMID: 2154691
DOI: 10.1016/0166-6851(90)90010-j

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2154691-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Alpha-difluoromethylornithine resistance in Leishmania donovani is associated with increased ornithine decarboxylase activity.PMID 2154691Read ↗

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