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Article

Genetic Manipulation of Leishmania donovani to Explore the Involvement of Argininosuccinate Synthase in Oxidative Stress Management.

PLoS neglected tropical diseases - 1 Mar 2016

Sardar Abul Hasan, Jardim Armando, Ghosh Ayan Kumar, Mandal Abhishek, Das Sushmita, Saini Savita, Abhishek Kumar, Singh Ruby, Verma Sudha, Kumar Ajay, Das Pradeep

Abstract excerpt

Reactive oxygen and nitrogen species (ROS and RNS) produced by the phagocytic cells are the most common arsenals used to kill the intracellular pathogens. However, Leishmania, an intracellular pathogen, has evolved mechanisms to survive by counterbalancing the toxic oxygen metabolites produced during infection. Polyamines, the major contributor in this anti-oxidant machinery, are largely dependent on the...

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PMID: 26939071
DOI: 10.1371/journal.pntd.0004308
PMCID: PMC4777552

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ASL

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Source receipt: pubmed, retrieved 7 Sept 2026.

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