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Article

Ornithine decarboxylase gene deletion mutants of Leishmania donovani.

The Journal of biological chemistry - 5 Feb 1999

Jiang Y, Roberts S C, Jardim A, Carter N S, Shih S, Ariyanayagam M, Fairlamb A H, Ullman B

Abstract excerpt

A knockout strain of Leishmania donovani lacking both ornithine decarboxylase (ODC) alleles has been created by targeted gene replacement. Growth of Deltaodc cells in polyamine-deficient medium resulted in a rapid and profound depletion of cellular putrescine pools, although levels of spermidine were relatively unaffected. Concentrations of trypanothione, a spermidine conjugate, were also reduced, whereas...

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Identifiers

PMID: 9920931
DOI: 10.1074/jbc.274.6.3781

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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