Trypanosoma brucei brucei: characterization of an ODC null bloodstream form mutant and the action of alpha-difluoromethylornithine.

doi:10.1006/expr.1998.4237

Back to search

Article

Trypanosoma brucei brucei: characterization of an ODC null bloodstream form mutant and the action of alpha-difluoromethylornithine.

Experimental parasitology - 1 Mar 1998

Li F, Hua S B, Wang C C, Gottesdiener K M

Abstract excerpt

Ornithine decarboxylase (ODC) is a key enzyme in the polyamine synthesis pathway in African trypanosomes. We report here the characterization of an ODC null bloodstream form Trypanosoma brucei brucei mutant, created by replacing the ODC gene with antibiotic resistant marker genes through transfec...

Topics

Animals
Culture Media
Drug Resistance
Eflornithine
Mice
Mice, Inbred BALB C
Mutation
Ornithine Decarboxylase
Putrescine
Trypanocidal Agents
Trypanosoma brucei brucei

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.