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Article

Alpha-difluoromethylornithine-resistant cell lines obtained after one-step selection of Leishmania mexicana promastigote cultures.

The Biochemical journal - 15 Jun 1997

Sánchez C P, Mucci J, González N S, Ochoa A, Zakin M M, Algranati I D

Abstract excerpt

Proliferation of Leishmania mexicana promastigotes in synthetic medium can be blocked by the depletion of intracellular polyamine pools induced by the presence of D,L-alpha-difluoromethylornithine (DFMO), a specific and irreversible inhibitor of ornithine decarboxylase (ODC). Here we report that...

Topics

Animals
Drug Resistance
Eflornithine
Enzyme Inhibitors
Gene Amplification
Leishmania mexicana
Ornithine Decarboxylase
Ornithine Decarboxylase Inhibitors
Phenotype
RNA, Messenger

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Identifiers

PMID: 9210409
DOI: 10.1042/bj3240847
PMCID: PMC1218501

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9210409-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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