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Article

Functional characterization of nucleoside transporter gene replacements in Leishmania donovani.

Molecular and biochemical parasitology - 1 Dec 2006

Liu Wei, Boitz Jan M, Galazka Jon, Arendt Cassandra S, Carter Nicola S, Ullman Buddy

Abstract excerpt

Leishmania donovani express two nucleoside transporters of non-overlapping ligand selectivity. To evaluate the physiological role of nucleoside transporters in L. donovani, homozygous null mutants of the genes encoding the LdNT1 adenosine-pyrimidine nucleoside transporter and the LdNT2 inosine-guanosine transporter were created singly and in combination by single targeted gene replacement followed by selection...

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Identifiers

PMID: 17050001
DOI: 10.1016/j.molbiopara.2006.09.002
PMCID: PMC1698457

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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