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Article

Evidence for Functional Protein Interactions Required for Poliovirus RNA Replication

12 May 2006

Abstract excerpt

Poliovirus protein 2C contains a predicted N-terminal amphipathic helix that mediates association of the protein with the membranes of the viral RNA replication complex. A chimeric virus that contains sequences encoding the 18-residue core from the orthologous amphipathic helix from human rhinovirus type 14 (HRV14) was constructed. The chimeric virus exhibited defects in viral RNA replication and produced minute...

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PMID: 16699013
DOI: 10.1128/jvi.02684-05

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