Article
A Single Amino Acid Substitution in Poliovirus Nonstructural Protein 2CATPase Causes Conditional Defects in Encapsidation and Uncoating.
Journal of virology - 15 Jul 2016
Asare Emmanuel, Mugavero JoAnn, Jiang Ping, Wimmer Eckard, Paul Aniko V
Abstract excerpt
UNLABELLED: The specificity of encapsidation of C-cluster enteroviruses depends on an interaction between capsid proteins and nonstructural protein 2C(ATPase) In particular, residue N252 of poliovirus 2C(ATPase) interacts with VP3 of coxsackievirus A20, in the context of a chimeric virus. Poliovi...
Topics
- Amino Acid Sequence
- Amino Acid Substitution
- Capsid
- Carrier Proteins
- HeLa Cells
- Host-Pathogen Interactions
- Humans
- Mutagenesis, Site-Directed
- Mutation
- Phenotype
- Poliomyelitis
- Poliovirus
- RNA, Viral
- Sequence Homology, Amino Acid
- Viral Nonstructural Proteins
- Virus Assembly
- Virus Replication
- Virus Uncoating