Article
A C-terminal, cysteine-rich site in poliovirus 2C(ATPase) is required for morphogenesis.
The Journal of general virology - 1 Jun 2014
Wang Chunling, Ma Hsin-Chieh, Wimmer Eckard, Jiang Ping, Paul Aniko V
Abstract excerpt
The morphogenesis of viruses belonging to the genus Enterovirus in the family Picornaviridae is still poorly understood despite decades-long investigations. However, we recently provided evidence that 2C(ATPase) gives specificity to poliovirus encapsidation through an interaction with capsid protein VP3. The polypeptide 2C(ATPase) is a highly conserved non-structural protein of enteroviruses with important roles...
Topics
- Adenosine Triphosphatases
- Amino Acid Sequence
- Binding Sites
- Carrier Proteins
- Conserved Sequence
- Genes, Viral
- HeLa Cells
- Humans
- Molecular Sequence Data
- Morphogenesis
- Mutation
- Phenotype
- Poliovirus
- Protein Biosynthesis