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Article

A cysteine-rich motif in poliovirus protein 2C(ATPase) is involved in RNA replication and binds zinc in vitro.

Journal of virology - 1 Jan 2000

Pfister T, Jones K W, Wimmer E

Abstract excerpt

Protein 2C(ATPase) of picornaviruses is involved in the rearrangement of host cell organelles, viral RNA replication, and encapsidation. However, the biochemical and molecular mechanisms by which 2C(ATPase) engages in these processes are not known. To characterize functional domains of 2C(ATPase), we have focused on a cysteine-rich motif near the carboxy terminus of poliovirus 2C(ATPase). This region, which is...

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Identifiers

PMID: 10590122
DOI: 10.1128/jvi.74.1.334-343.2000
PMCID: PMC111544

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Source receipt: pubmed, retrieved 7 Sept 2026.

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