Article
Characterization of a transforming N-ras gene in the human hepatoma cell line Hep G2: additional evidence for the importance of c-myc and ras cooperation in hepatocarcinogenesis.
Cancer research - 1 Mar 1990
Richards C A, Short S A, Thorgeirsson S S, Huber B E
Abstract excerpt
The expression of the c-myc gene has previously been shown to be elevated and deregulated in the human hepatoma cell line Hep G2 (B. E. Huber and S. S. Thorgeirsson, Cancer Res., 47: 3414-3420, 1987). We now report that the Hep G2 N-ras gene is activated to a dominant-acting, transforming gene by...
Topics
- Alleles
- Animals
- Base Sequence
- Blotting, Northern
- Carcinoma, Hepatocellular
- Cell Division
- Codon
- Gene Amplification
- Genes, Dominant
- Genes, ras
- Humans
- Liver Neoplasms
- Mice
- Mice, Nude
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Protein Biosynthesis