Article
Stat3 plays an important role in oncogenic Ros- and insulin-like growth factor I receptor-induced anchorage-independent growth.
The Journal of biological chemistry - 23 Oct 1998
Zong C S, Zeng L, Jiang Y, Sadowski H B, Wang L H
Abstract excerpt
The role of signal transducers and activators of transcription (STATs) in receptor protein-tyrosine kinase (PTK)-induced cell growth and transformation was investigated using an inducible epidermal growth factor receptor-Ros chimeric receptor called ER2 and a constitutively activated insulin-like growth factor I receptor called NM1, both of which are able to induce anchorage-independent growth of NIH 3T3 cells....
Topics
- 3T3 Cells
- Animals
- Cell Transformation, Neoplastic
- DNA-Binding Proteins
- Epidermal Growth Factor
- Mice
- Mutation
- Oncogene Proteins, Viral
- Phosphorylation
- Protein Binding
- Receptor Protein-Tyrosine Kinases
- Receptor, IGF Type 1
- STAT3 Transcription Factor
- Signal Transduction