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Article

Overexpression of insulin receptors in fibroblast and ovary cells induces a ligand-mediated transformed phenotype.

Molecular endocrinology (Baltimore, Md.) - 1 Mar 1991

Giorgino F, Belfiore A, Milazzo G, Costantino A, Maddux B, Whittaker J, Goldfine I D, Vigneri R

Abstract excerpt

To investigate whether overexpression of the insulin receptor results in altered cell growth we used NIH 3T3 cells transfected with a bovine papilloma virus/insulin receptor cDNA construct (3T3/HIR). These cells expressed high numbers of insulin receptors (mean +/- sd, 631.0 +/- 16.7 ng receptors/10(6) cells). Insulin significantly stimulated the growth of 3T3/HIR cells maintained in serum-free medium. Moreover,...

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Identifiers

PMID: 1653897
DOI: 10.1210/mend-5-3-452

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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