Overexpression of insulin receptors in fibroblast and ovary cells induces a ligand-mediated transformed phenotype.

doi:10.1210/mend-5-3-452

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Article

Overexpression of insulin receptors in fibroblast and ovary cells induces a ligand-mediated transformed phenotype.

Molecular endocrinology (Baltimore, Md.) - 1 Mar 1991

Giorgino F, Belfiore A, Milazzo G, Costantino A, Maddux B, Whittaker J, Goldfine I D, Vigneri R

Abstract excerpt

To investigate whether overexpression of the insulin receptor results in altered cell growth we used NIH 3T3 cells transfected with a bovine papilloma virus/insulin receptor cDNA construct (3T3/HIR). These cells expressed high numbers of insulin receptors (mean +/- sd, 631.0 +/- 16.7 ng receptors/10(6) cells). Insulin significantly stimulated the growth of 3T3/HIR cells maintained in serum-free medium. Moreover,...

Topics

Agar
Animals
Cell Line
DNA
Drug Resistance
Female
Fibroblasts
Gene Expression
Insulin
Mice
Mice, Nude
Neomycin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ovary

Papillomaviridae

Phenotype

Receptor, Insulin

Transfection

Transformation, Genetic

Source

Open in PubMed

Identifiers

PMID: 1653897
DOI: 10.1210/mend-5-3-452

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1653897-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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