Article
Insulin receptor overexpression in 184B5 human mammary epithelial cells induces a ligand-dependent transformed phenotype.
Journal of cellular biochemistry - 1 Apr 1995
Frittitta L, Vigneri R, Stampfer M R, Goldfine I D
Abstract excerpt
To determine the role of the insulin receptor overexpression in breast epithelial cell transformation, the 184B5 human breast epithelial cell line was transfected with human insulin receptor cDNA. In two cell lines transfected with and overexpressing human insulin receptors (IR) (223.8 and 184.5...
Topics
- Binding Sites
- Binding, Competitive
- Blotting, Western
- Breast
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- DNA, Complementary
- Dose-Response Relationship, Drug
- Epithelium
- Humans
- Insulin
- Ligands
- Phenotype
- Protein-Tyrosine Kinases
- Radioimmunoassay
- Receptor, Insulin
- Transcriptional Activation
- Transfection