Regulation of macrophage function by interferon-gamma. Somatic cell genetic approaches in murine macrophage cell lines to mechanisms of growth inhibition, the oxidative burst, and expression of the chronic granulomatous disease gene.

Abstract excerpt

The importance of oxidative cytocidal mechanisms of phagocytic cells in immune protection against microbial pathogens is uniquely revealed by chronic granulomatous disease (CGD), a genetic deficiency disease of man. This cytocidal response in mononuclear phagocytes is principally regulated by IFN...

Topics

• Animals
• Cell Line
• Gene Expression
• Granulomatous Disease, Chronic
• Interferon-gamma
• Macrophages
• Mice
• Mutation
• Oxidation-Reduction
• Superoxides
• Tetradecanoylphorbol Acetate