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Article

In vivo interferon-gamma induced changes in gene expression dramatically alter neutrophil phenotype.

PloS one - 1 Jan 2022

Ambruso Daniel R, Briones Natalie J, Baroffio Angelina F, Murphy John R, Tran Alexander D, Gowan Katherine, Sanford Bridget, Ellison Michael, Jones Kenneth L

Abstract excerpt

The cytokine Interferon-γ (IFN-γ) exerts powerful immunoregulatory effects on the adaptive immune system and also enhances functions of the neutrophil (PMN). The clinical use of IFN-γ has been driven by the finding that its administration to patients with chronic granulomatous disease (CGD) results in decreased incidence and severity of infections. However, IFN-γ has no effect on the characteristic defect of CGD,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35113934
DOI: 10.1371/journal.pone.0263370
PMCID: PMC8812922

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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