Article
Enhanced generation of reactive oxygen species by interferon-γ may have contributed to successful treatment of invasive pulmonary aspergillosis in a patient with chronic granulomatous disease.
International journal of hematology - 1 Apr 2013
Yamashita Kouhei, Miyoshi Takashi, Arai Yasuyuki, Mizugishi Kiyomi, Takaori-Kondo Akifumi, Ueyama Takehiko
Abstract excerpt
Invasive pulmonary aspergillosis (IPA) is a life-threatening complication of chronic granulomatous disease (CGD), a rare inherited disorder of phagocytes that is characterized by a defect in the production of reactive oxygen species (ROS) caused by mutations in NADPH oxidase 2. Here, we report a case of successful treatment of IPA complicated with CGD by the administration of interferon-γ (IFN-γ) in combination...
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