Restoration of phagocyte function by interferon-gamma in X-linked chronic granulomatous disease occurs at the level of a progenitor cell.

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Article

Restoration of phagocyte function by interferon-gamma in X-linked chronic granulomatous disease occurs at the level of a progenitor cell.

Blood - 15 Dec 1990

Ezekowitz R A, Sieff C A, Dinauer M C, Nathan D G, Orkin S H, Newburger P E

Abstract excerpt

Phagocytes from X-linked chronic granulomatous disease (X-CGD) patients are deficient in their ability to generate superoxide because of a defective gene that encodes a heavy chain of cytochrome b, a critical component in the superoxide-generating pathway. Previously we have shown that a single i...

Topics

Cell Differentiation
Genetic Linkage
Granulomatous Disease, Chronic
Hematopoietic Stem Cells
Histocytochemistry
Humans
Interferon-gamma
Nitroblue Tetrazolium
Phagocytes
Phenotype
Superoxides
X Chromosome

Source

Open in PubMed

Identifiers

PMID: 2176110

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2176110-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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