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Article

Mutagenesis associated with nitric oxide production in macrophages.

Proceedings of the National Academy of Sciences of the United States of America - 7 Jul 1998

Zhuang J C, Lin C, Lin D, Wogan G N

Abstract excerpt

To better understand the mechanisms through which persistent infections/inflammation increase cancer risks, we assessed the potential genotoxic properties of NO produced by macrophages. We recently showed that mouse macrophage RAW264.7 cells were capable of resuming exponential growth after stimulation for NO production by interferon-gamma (IFN-gamma) and/or lipopolysaccharide. Here, we report that increases in...

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Identifiers

PMID: 9653179
DOI: 10.1073/pnas.95.14.8286
PMCID: PMC20968

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