Mutagenesis associated with nitric oxide production in macrophages.

doi:10.1073/pnas.95.14.8286

Back to search

Article

Mutagenesis associated with nitric oxide production in macrophages.

Proceedings of the National Academy of Sciences of the United States of America - 7 Jul 1998

Zhuang J C, Lin C, Lin D, Wogan G N

Abstract excerpt

To better understand the mechanisms through which persistent infections/inflammation increase cancer risks, we assessed the potential genotoxic properties of NO produced by macrophages. We recently showed that mouse macrophage RAW264.7 cells were capable of resuming exponential growth after stimu...

Topics

Animals
Cell Line
Gene Expression Regulation
Hypoxanthine Phosphoribosyltransferase
Interferon-gamma
Macrophage Activation
Macrophages
Mice
Mutagenesis
Mutation
Nitric Oxide

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.