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Article

Retrovirus-mediated reconstitution of respiratory burst activity in X-linked chronic granulomatous disease cells.

Blood - 15 Nov 1994

Kume A, Dinauer M C

Abstract excerpt

X-linked chronic granulomatous disease (X-CGD) results from mutations in the gene encoding gp91phox, the larger subunit of the respiratory burst oxidase cytochrome b. In this study, a recombinant retrovirus vector was constructed and evaluated for its expression of human gp91phox in a human X-CGD myeloid cell line in which the endogenous gp91phox gene had been disrupted by gene targeting. The retrovirus...

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PMID: 7949086

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