Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting Ergosterol Biosynthesis in Leishmania donovani: Essentiality of Sterol 14alpha-demethylase

13 Mar 2015

Abstract excerpt

Leishmania protozoan parasites (Trypanosomatidae family) are the causative agents of cutaneous, mucocutaneous and visceral leishmaniasis worldwide. While these diseases are associated with significant morbidity and mortality, there are few adequate treatments available. Sterol 14alpha-demethylase (CYP51) in the parasite sterol biosynthesis pathway has been the focus of considerable interest as a novel drug target...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Helminth infection and control
Share to Research on Leishmaniasis Studies
Share to Trypanosoma species research and implications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25768284
DOI: 10.1371/journal.pntd.0003588

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting Ergosterol Biosynthesis in Leishmania donovani: Essentiality of Sterol 14alpha-demethylasePMID 25768284Read ↗

CYP5122A1, a Novel Cytochrome P450 Is Essential for Survival of Leishmania donovaniSemantic proximity Read ↗

CYP5122A1 encodes an essential sterol C4-methyl oxidase in Leishmania donovani and determines the antileishmanial activity of antifungal azolesSemantic proximity Read ↗

Sterol 14-alpha demethylase (CYP51) activity in Leishmania donovani is likely dependent upon cytochrome P450 reductase 1Semantic proximity Read ↗

A Plant like Cytochrome P450 Subfamily CYP710C1 Gene in Leishmania donovani Encodes Sterol C-22 Desaturase and its Over-expression Leads to Resistance to Amphotericin BSemantic proximity Read ↗

Sterol methyltransferase is required for optimal mitochondrial function and virulence in Leishmania majorSemantic proximity Read ↗

Functional analysis of an AMP forming acetyl CoA synthetase from Leishmania donovani by gene overexpression and targeted gene disruption approaches.Semantic proximity Read ↗

Sterol 14α-demethylase mutation leads to amphotericin B resistance in Leishmania mexicana.Semantic proximity Read ↗

Trypanosoma brucei CYP51: Essentiality and Targeting Therapy in an Experimental Model.Semantic proximity Read ↗

Genetically Validated Drug Targets in Leishmania: Current Knowledge and Future ProspectsSemantic proximity Read ↗

Emerging therapeutic targets for treatment of leishmaniasisSemantic proximity Read ↗

Recent advances in Leishmania reverse genetics: Manipulating a manipulative parasiteSemantic proximity Read ↗

Phenotypic Characterization of a Leishmania donovani Cyclophilin 40 Null Mutant.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.