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Article

Deletion of Glutamine Synthetase Gene Disrupts the Survivability and Infectivity of Leishmania donovani.

Frontiers in cellular and infection microbiology - 1 Jan 2021

Kumar Vinay, Ghosh Sanhita, Roy Kamalika, Pal Chiranjib, Singh Sushma

Abstract excerpt

Glutamine synthetase (GS) is one of the most important metabolic enzymes which catalyzes ligation of glutamate and ammonia to form glutamine. Previous studies from our lab had revealed significant differences in parasite and host GS enzyme which warranted us to further work on its relevance in parasite. To analyze glutamine synthetase function in Leishmania, we generated GS overexpressors and knockout mutants and...

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Identifiers

PMID: 33732662
DOI: 10.3389/fcimb.2021.622266
PMCID: PMC7959746

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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