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Article

Non-canonical Wnt induces chondrocyte de-differentiation through Frizzled 6 and DVL-2/B-raf/CaMKIIα/syndecan 4 axis.

Cell death and differentiation - 1 Aug 2018

Xie Zhe, Khair Mostafa, Shaukat Irfan, Netter Patrick, Mainard Didier, Barré Lydia, Ouzzine Mohamed

Abstract excerpt

Dysregulation of Wnt signaling has been implicated in developmental defects and in the pathogenesis of many diseases such as osteoarthritis; however, the underlying mechanisms are poorly understood. Here, we report that non-canonical Wnt signaling induced loss of chondrocyte phenotype through activation of Fz-6/DVL-2/SYND4/CaMKIIα/B-raf/ERK1/2 cascade. We show that in response to Wnt-3a, Frizzled 6 (Fz-6)...

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Identifiers

PMID: 29352270
DOI: 10.1038/s41418-017-0050-y
PMCID: PMC6113213

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