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Article

Wnt-7a causes loss of differentiated phenotype and inhibits apoptosis of articular chondrocytes via different mechanisms.

The Journal of biological chemistry - 18 Jun 2004

Hwang Sang-Gu, Ryu Je-Hwang, Kim Il-Chul, Jho Eek-Hoon, Jung Ho-Chul, Kim Kwonseop, Kim Song-Ja, Chun Jang-Soo

Abstract excerpt

Although regulation of chondrogenesis and cartilage development by Wnt signaling is well established, the function of Wnt in the maintenance and destruction of cartilage remains largely unknown. Here we investigated the involvement and regulatory mechanisms of Wnt signaling in cartilage destruction. We found that interleukin-1beta, the primary pro-inflammatory cytokine involved in cartilage destruction, induces...

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Source

Identifiers

PMID: 15082716
DOI: 10.1074/jbc.M401401200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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