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Single-cell RNA-seq analysis reveals the Wnt/Ca2+ signaling pathway with inflammation, apoptosis in nucleus pulposus degeneration

23 Apr 2024

Abstract excerpt

Abstract Background Increasing studies have shown degeneration of nucleus pulposus cells (NPCs) as an critical part of the progression of intervertebral disc degeneration (IVDD). However, there are relatively few studies on single-cell transcriptome contrasts in human degenerated NPCs. Moreover, differences in Wnt/Ca 2+ signaling in human degenerated nucleus pulposus cells have not been elucidated. The aim of...

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PMID: 38654287
DOI: 10.1186/s12891-024-07368-3

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