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Article

Elevated Dickkopf-2 levels contribute to the abnormal phenotype of human osteoarthritic osteoblasts.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jul 2011

Chan Thomas F, Couchourel Denis, Abed Elie, Delalandre Aline, Duval Nicolas, Lajeunesse Daniel

Abstract excerpt

The Wnt signaling pathway is crucial for osteogenesis and regulates terminal osteoblast differentiation. Although osteoarthritic (OA) osteoblasts show an abnormal phenotype and poor in vitro mineralization, the mechanism leading to this situation still remains unknow. Recent evidence indicates that Wnt signaling may be altered in OA osteoblasts. In this study we determined whether an alteration of the...

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Source

Identifiers

PMID: 21312269
DOI: 10.1002/jbmr.358

Genes

DKK2
DKK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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