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Article

Dickkopf-3 is upregulated in osteoarthritis and has a chondroprotective role

17 Dec 2015

Abstract excerpt

OBJECTIVE: Dickkopf-3 (Dkk3) is a non-canonical member of the Dkk family of Wnt antagonists and its upregulation has been reported in microarray analysis of cartilage from mouse models of osteoarthritis (OA). In this study we assessed Dkk3 expression in human OA cartilage to ascertain its potential role in chondrocyte signaling and cartilage maintenance. METHODS: Dkk3 expression was analysed in human adult OA...

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PMID: 26687825
DOI: 10.1016/j.joca.2015.11.021

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