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Article

Non-Canonical WNT5A Signaling Through RYK Contributes to Aggressive Phenotype of the Rheumatoid Fibroblast-Like Synoviocytes.

Frontiers in immunology - 1 Jan 2020

Rodriguez-Trillo Angela, Mosquera Nerea, Pena Carmen, Rivas-Tobío Fatima, Mera-Varela Antonio, Gonzalez Antonio, Conde Carmen

Abstract excerpt

We hypothesized that WNT5A could contribute to the enhanced migration and invasiveness of rheumatoid arthritis fibroblast-like synoviocytes (RA FLS), which is one of the incompletely understood aspects of the RA FLS aggressive phenotype. This hypothesis is based on the previous evidence of a WNT5A role in both, RA and cell migration. Migration and invasion of RA FLS were assessed after incubation with recombinant...

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Identifiers

PMID: 33178184
DOI: 10.3389/fimmu.2020.555245
PMCID: PMC7593687

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