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Article

Expression of a dominant negative PKA mutation in the kidney elicits a diabetes insipidus phenotype.

American journal of physiology. Renal physiology - 15 Mar 2015

Gilbert Merle L, Yang Linghai, Su Thomas, McKnight G Stanley

Abstract excerpt

PKA plays a critical role in water excretion through regulation of the production and action of the antidiuretic hormone arginine vasopressin (AVP). The AVP prohormone is produced in the hypothalamus, where its transcription is regulated by cAMP. Once released into the circulation, AVP stimulates...

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Share to Aquaporin 2
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Share to Cyclic AMP-Dependent Protein Kinase RIalpha Subunit

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25587115
DOI: 10.1152/ajprenal.00222.2014
PMCID: PMC4360038

Genes

AQP2
AVP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25587115-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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