Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic evidence for an interaction between a picornaviral cis-acting RNA replication element and 3CD protein.

The Journal of biological chemistry - 26 Mar 2004

Yang Yan, Rijnbrand Rene, Watowich Stanley, Lemon Stanley M

Abstract excerpt

Internally located, cis-acting RNA replication elements, termed cres, are essential for replication of the genomes of picornaviruses such as human rhinovirus 14 (HRV-14) and poliovirus because they template uridylylation of the protein primer, VPg, by the polymerase 3D(pol). These cres form stem-loop structures sharing a common loop motif, and the HRV-14 cre can substitute functionally for the poliovirus cre in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Integrases
Share to Luciferases
Share to Nucleic Acid Conformation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Picornaviridae

Share to Protein Structure, Secondary

Share to Response Elements

Share to Viral Proteins

Source

Identifiers

PMID: 14711816
DOI: 10.1074/jbc.M312992200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic evidence for an interaction between a picornaviral cis-acting RNA replication element and 3CD protein.PMID 14711816Read ↗

Structure and function analysis of the poliovirus <i>cis</i>-acting replication element (CRE)Semantic proximity Read ↗

Sequence Requirements for Viral RNA Replication and VPg Uridylylation Directed by the Internal <i>cis</i> -Acting Replication Element ( <i>cre</i> ) of Human Rhinovirus Type 14Semantic proximity Read ↗

Human rhinovirus type 14 gain-of-function mutants for oriI utilization define residues of 3C(D) and 3Dpol that contribute to assembly and stability of the picornavirus VPg uridylylation complex.Semantic proximity Read ↗

The rhinovirus type 14 genome contains an internally located RNA structure that is required for viral replicationSemantic proximity Read ↗

Genetic and biochemical studies of poliovirus cis-acting replication element cre in relation to VPg uridylylation.Semantic proximity Read ↗

Functional dissection of a poliovirus cis-acting replication element [PV-cre(2C)]: analysis of single- and dual-cre viral genomes and proteins that bind specifically to PV-cre RNA.Semantic proximity Read ↗

Similar interactions of the poliovirus and rhinovirus 3D polymerases with the 3' untranslated region of rhinovirus 14.Semantic proximity Read ↗

Identification of a conserved RNA replication element (cre) within the 3Dpol-coding sequence of hepatoviruses.Semantic proximity Read ↗

The cis-acting replication elements define human enterovirus and rhinovirus speciesSemantic proximity Read ↗

Structural basis for a highly conserved RNA-mediated enteroviral genome replicationSemantic proximity Read ↗

Both <i>cis</i> and <i>trans</i> Activities of Foot-and-Mouth Disease Virus 3D Polymerase Are Essential for Viral RNA ReplicationSemantic proximity Read ↗

Insight into poliovirus genome replication and encapsidation obtained from studies of 3B-3C cleavage site mutants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.