Article
Poliovirus proteinase 3C converts an active form of transcription factor IIIC to an inactive form: a mechanism for inhibition of host cell polymerase III transcription by poliovirus.
The EMBO journal - 1 Oct 1991
Clark M E, Hämmerle T, Wimmer E, Dasgupta A
Abstract excerpt
In HeLa cells, RNA polymerase III (pol III)-mediated transcription is severely inhibited by poliovirus infection. This is due primarily to a reduction in the transcriptional activity of TFIIIC, a transcription factor which binds in a sequence specific manner to the internal promoter of pol III ge...
Topics
- 3C Viral Proteases
- Cysteine Endopeptidases
- Escherichia coli
- Genes, Bacterial
- HeLa Cells
- Humans
- Hydrolysis
- Mutation
- RNA Polymerase III
- Transcription Factors
- Transcription Factors, TFIII
- Transcription, Genetic
- Transfection
- Viral Proteins
- Transcription Factor TFIIIC