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Article

Crystal Structure of the Simian Virus 40 Large T-Antigen Origin-Binding Domain

12 Apr 2006

Abstract excerpt

The origins of replication of DNA tumor viruses have a highly conserved feature, namely, multiple binding sites for their respective initiator proteins arranged as inverted repeats. In the 1.45-angstroms crystal structure of the simian virus 40 large T-antigen (T-ag) origin-binding domain (obd) reported herein, T-ag obd monomers form a left-handed spiral with an inner channel of 30 angstroms having six monomers...

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PMID: 16611889
DOI: 10.1128/jvi.80.9.4304-4312.2006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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