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Article

The NFKB1 (g.-24519delATTG) variant is associated with necrotizing enterocolitis (NEC) in premature infants.

The Journal of surgical research - 1 Jul 2011

Sampath Venkatesh, Le Min, Lane Laura, Patel Aloka L, Cohen Jonathan D, Simpson Pippa M, Garland Jeffery S, Hines Ronald N

Abstract excerpt

OBJECTIVE: While it is known that gene-environment interactions contribute to necrotizing enterocolitis (NEC) pathogenesis, characterization of genetic risk-factors that can predict NEC in preterm infants remains nascent. We hypothesized that altered intestinal immune responses arising from sequence variation in the toll-like receptor (TLR) pathway genes contribute to NEC susceptibility. MATERIALS AND METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21529841
DOI: 10.1016/j.jss.2011.03.017

Genes

NFKB1
NFKBIA
IRAK1
TIRAP
TLR2
TLR4
TLR5
TLR9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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