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Article

SIGIRR genetic variants in premature infants with necrotizing enterocolitis.

Pediatrics - 1 Jun 2015

Sampath Venkatesh, Menden Heather, Helbling Daniel, Li Keguo, Gastonguay Adam, Ramchandran Ramani, Dimmock David P

Abstract excerpt

Necrotizing enterocolitis (NEC) is a severe form of bowel disease that develops in premature infants. Although animal data and human studies suggest that aberrant activation of the intestinal immune system contributes to NEC, the pathogenesis remains unclear. We hypothesized that inherited defects in the regulation of Toll-like receptor signaling can contribute to NEC susceptibility in premature infants. A...

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Source

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Identifiers

PMID: 25963006
DOI: 10.1542/peds.2014-3386
PMCID: PMC4444800

Genes

SIGIRR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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