Article
A TLR5 (g.1174C > T) variant that encodes a stop codon (R392X) is associated with bronchopulmonary dysplasia.
Pediatric pulmonology - 1 May 2012
Sampath Venkatesh, Garland Jeffery S, Le Min, Patel Aloka L, Konduri Girija G, Cohen Jonathan D, Simpson Pippa M, Hines Ronald N
Abstract excerpt
Current evidence supports a major role for inherited factors in determining bronchopulmonary dysplasia (BPD) susceptibility. The Toll-like receptor (TLR) family of proteins maintain pulmonary homeostasis in the developing lung by aiding pathogen recognition and clearance, regulating inflammation, and facilitating reparative tissue growth. We hypothesized that sequence variation in the TLR pathway genes would...
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