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Article

Surgical necrotizing enterocolitis in extremely premature neonates is associated with genetic variations in an intergenic region of chromosome 8.

Pediatric research - 1 May 2018

Jilling Tamas, Ambalavanan Namasivayam, Cotten C Michael, Martin Colin A, Maheshwari Akhil, Schibler Kurt, Levy Joshua, Page Grier P

Abstract excerpt

BackgroundTwin studies suggest that genetic factors may account for up to 50% increased risk for necrotizing enterocolitis (NEC), but genome-wide association studies for NEC are lacking.MethodsGenotyping was done on Illumina BeadChip, followed by analysis using PLINK with logistic regression under an additive model.ResultsAmong 751 extremely-low-birth-weight (<1,000 g, >401 g) neonates, 30 had surgical NEC. Two...

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Share to Chromosomes, Human, Pair 8
Share to DNA, Intergenic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Infant, Newborn, Diseases

Share to Infant, Premature

Share to Long Interspersed Nucleotide Elements

Share to Oligonucleotide Array Sequence Analysis

Share to Respiration, Artificial

Share to Sequence Analysis, RNA

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Identifiers

PMID: 29538362
DOI: 10.1038/pr.2018.33
PMCID: PMC6053310

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