Article
Differential activity of NADPH-producing dehydrogenases renders rodents unsuitable models to study IDH1R132 mutation effects in human glioblastoma.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society - 1 May 2011
Atai Nadia A, Renkema-Mills Nynke A, Bosman Joost, Schmidt Nadja, Rijkeboer Denise, Tigchelaar Wikky, Bosch Klazien S, Troost Dirk, Jonker Ard, Bleeker Fonnet E, Miletic Hrvoje, Bjerkvig Rolf, De Witt Hamer Philip C, Van Noorden Cornelis J F
Abstract excerpt
The somatic IDH1(R132) mutation in the isocitrate dehydrogenase 1 gene occurs in high frequency in glioma and in lower frequency in acute myeloid leukemia and thyroid cancer but not in other types of cancer. The mutation causes reduced NADPH production capacity in glioblastoma by 40% and is associated with prolonged patient survival. NADPH is a major reducing compound in cells that is essential for detoxification...
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