Article
NADP+ -dependent IDH1 R132 mutation and its relevance for glioma patient survival.
Medical hypotheses - 1 Jun 2013
Baldewpersad Tewarie Nishita M S, Burgers Ilsa A V, Dawood Yousif, den Boon Hannah C, den Brok Melina G H E, Klunder Jet H, Koopmans Kristijn B, Rademaker Emma, van den Broek Hans B, van den Bersselaar Sil M, Witjes Julia J, Van Noorden Cornelis J F, Atai Nadia A
Abstract excerpt
The isocitrate dehydrogenase 1 (IDH1) mutation occurs in high frequency in glioma and secondary glioblastoma (GBM). Mutated IDH1 produces the oncometabolite 2-hydroxyglutarate rather than α-ketoglutarate or isocitrate. The oncometabolite is considered to be the major cause of the association between the IDH1 mutation and gliomagenesis. On the other hand, the IDH1 mutation in GBM is associated with prolonged...
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