Article
Functional alteration of canine isocitrate dehydrogenase 2 (IDH2) via an R174K mutation.
The Journal of veterinary medical science - 27 Jan 2018
Kawakami Shota, Ochiai Kazuhiko, Kato Yuiko, Michishita Masaki, Hirama Hinako, Obara Ryo, Azakami Daigo, Watanabe Masami, Omi Toshinori
Abstract excerpt
Gliomas are common intracranial neoplasias in dogs. However, the underlying pathogenic mechanisms remain unclear. In humans, isocitrate dehydrogenase 2 (IDH2) is often mutated in gliomas. Although almost human IDH2 mutations have been identified at the Arg172 codon, few studies have reported structural, functional or mutational information for canine IDH2. In this study, we cloned the full-length canine IDH2...
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