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Article

The prognostic IDH1( R132 ) mutation is associated with reduced NADP+-dependent IDH activity in glioblastoma.

Acta neuropathologica - 1 Apr 2010

Bleeker Fonnet E, Atai Nadia A, Lamba Simona, Jonker Ard, Rijkeboer Denise, Bosch Klazien S, Tigchelaar Wikky, Troost Dirk, Vandertop W Peter, Bardelli Alberto, Van Noorden Cornelis J F

Abstract excerpt

Somatic mutations in the isocitrate dehydrogenase 1 gene (IDH1) occur at high frequency in gliomas and seem to be a prognostic factor for survival in glioblastoma patients. In our set of 98 glioblastoma patients, IDH1 ( R132 ) mutations were associated with improved survival of 1 year on average,...

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Source

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Identifiers

PMID: 20127344
DOI: 10.1007/s00401-010-0645-6
PMCID: PMC2841753

Genes

IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20127344-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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