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Article

Radioprotection of IDH1-Mutated Cancer Cells by the IDH1-Mutant Inhibitor AGI-5198.

Cancer research - 15 Nov 2015

Molenaar Remco J, Botman Dennis, Smits Myrthe A, Hira Vashendriya V, van Lith Sanne A, Stap Jan, Henneman Peter, Khurshed Mohammed, Lenting Krissie, Mul Adri N, Dimitrakopoulou Dionysia, van Drunen Cornelis M, Hoebe Ron A, Radivoyevitch Tomas, Wilmink Johanna W, Maciejewski Jaroslaw P, Vandertop W Peter, Leenders William P, Bleeker Fonnet E, van Noorden Cornelis J

Abstract excerpt

Isocitrate dehydrogenase 1 (IDH1) is mutated in various types of human cancer to IDH1(R132H), a structural alteration that leads to catalysis of α-ketoglutarate to the oncometabolite D-2-hydroxyglutarate. In this study, we present evidence that small-molecule inhibitors of IDH1(R132H) that are being developed for cancer therapy may pose risks with coadministration of radiotherapy. Cancer cells heterozygous for...

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Source

Identifiers

PMID: 26363012
DOI: 10.1158/0008-5472.CAN-14-3603

Genes

IDH1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Radioprotection of IDH1-Mutated Cancer Cells by the IDH1-Mutant Inhibitor AGI-5198.PMID 26363012Read ↗

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IDH1 <sup>R132H</sup> acts as a tumor suppressor in glioma via epigenetic upregulation of the DNA damage responseSemantic proximity Read ↗

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