Article
Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genome-wide forward genetic screen in human colorectal cancer cells.
Genome medicine - 4 Jan 2018
Kundu Snehangshu, Ali Muhammad Akhtar, Handin Niklas, Padhan Narendra, Larsson Jimmy, Karoutsou Maria, Ban Kenneth, Wiśniewski Jacek R, Artursson Per, He Liqun, Hellström Mats, Sjöblom Tobias
Abstract excerpt
BACKGROUND: The Ras pathway genes KRAS, BRAF, or ERBBs have somatic mutations in ~ 60% of human colorectal carcinomas. At present, it is unknown whether the remaining cases lack mutations activating the Ras pathway or whether they have acquired mutations in genes hitherto unknown to belong to the pathway. METHODS: To address the second possibility and extend the compendium of Ras pathway genes, we used...
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