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Article

Escaping an evolutionary lobster trap: drug resistance and compensatory mutation in a fluctuating environment.

Evolution; international journal of organic evolution - 1 May 2011

Tanaka Mark M, Valckenborgh Frank

Abstract excerpt

The fitness landscape concept aids intuition on adaptive evolution through low fitness genotypes. Evolutionary processes become complex when environments and therefore fitnesses fluctuate. Antibiotic resistance evolution in bacteria is an important example of such dynamics. Resistance bears a cost in the drug-free environment, but compensatory mutation can lower this cost, creating a fitness valley. With the drug...

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PMID: 21521192
DOI: 10.1111/j.1558-5646.2011.01223.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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