Dynamics of evolutionary rescue in changing environments and the emergence of antibiotic resistance.

doi:10.1016/j.jtbi.2013.09.026

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Dynamics of evolutionary rescue in changing environments and the emergence of antibiotic resistance.

Journal of theoretical biology - 7 Jan 2014

Wu Yue, Saddler Clare A, Valckenborgh Frank, Tanaka Mark M

Abstract excerpt

Populations can go extinct when their environments deteriorate, but evolutionary rescue occurs when a shrinking population adapts to the new environmental conditions. The emergence of resistance from a drug sensitive bacterial population under treatment can be regarded as an instance of evolutionary rescue. Understanding evolutionary rescue in a particular context such as drug resistance requires knowledge of how...

Topics

Anti-Bacterial Agents
Bacteria
Bacterial Infections
Computer Simulation
Dose-Response Relationship, Drug
Drug Resistance, Bacterial
Environment
Genes, Bacterial
Genotype
Humans
Models, Biological
Mutation
Poisson Distribution
Probability
Selection, Genetic

Source

Open in PubMed

Identifiers

PMID: 24076261
DOI: 10.1016/j.jtbi.2013.09.026

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics