Limits to compensatory adaptation and the persistence of antibiotic resistance in pathogenic bacteria

Abstract excerpt

Antibiotic resistance carries a fitness cost that could potentially limit the spread of resistance in bacterial pathogens. In spite of this cost, a large number of experimental evolution studies have found that resistance is stably maintained in the absence of antibiotics as a result of compensatory evolution. Clinical studies, on the other hand, have found that resistance in pathogen populations usually declines...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Antibiotic Resistance in Bacteria
• Share to Burkholderia infections and melioidosis
• Share to Evolution and Genetic Dynamics